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6-amino quinazoline 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof
专利权人:
Jiangsu Hengrui Medicine Co., Ltd.;Shanghai Hengrui Pharmaceutical Co. Ltd.
发明人:
TANG, Peng Cho,LI, Xin,WANG, Bin,WANG, Jun,CHEN, Lijun
申请号:
ES10814867
公开号:
ES2647829T3
申请日:
2010.08.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of the formula (I) and pharmaceutically acceptable tautomers, enantiomers, diastereomers, racemates and salts thereof, ** Formula ** in which: A is selected from the group consisting of a carbon atom or a nitrogen atom; When A is a carbon atom, R1 is selected from the group consisting of hydrogen or alkoxy; wherein said alkoxy is optionally further substituted by one or more groups selected from the group consisting of halogen or alkoxy; R2 is cyano; When A is a nitrogen atom, R1 is selected from the group consisting of hydrogen or alkoxy; wherein said alkoxy is optionally further substituted by one or more groups selected from the group consisting of halogen or alkoxy; R2 is absent; R3 is a radical having the following formula: ** Formula ** or -D; wherein D is selected from the group consisting of aryl or heteroaryl, wherein said aryl or heteroaryl is each independently optionally and additionally substituted by one or more groups selected from the group consisting of halogen, alkyl or trifluoromethyl; T is selected from the group consisting of - (CH2) r, -O (CH2) r, -NH (CH2) -r or -S (O) r (CH2) r-; L is selected from the group consisting of aryl or heteroaryl, wherein said aryl or heteroaryl are each optionally independently and additionally substituted by one or more groups selected from the group consisting of halogen or alkyl; R4 and R5 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, hydroxyl, hydroxyalkyl, halogen, carbonyl, amino, cyano, nitro, carboxy, or carboxylic ester; B is selected from the group consisting of carbon atoms, oxygen atom, or S (O) r; When B un is a carbon atom, R6 and R7 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, hydroxyl, hydroxyalkyl, halogen, carbonyl, amino, cyano, nitro, carboxy or carboxylic ester; When B is an oxygen atom or S (O) r, R6 and R7 are absent; R8 is selected from the group consisting of hydrogen or alkyl; R9 is selected from th
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