Compounds useful as AMPK activators.expression: Wherein X is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl , Substituted or unsubstituted cycloalkenyl or substituted or unsubstituted heterocyclyl, ROneSubstituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylthio, , Substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl or substituted or unsubstituted alkyloxycarbonyl, R2Is selected from the group consisting of halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted Or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl and the like, and R3Is selected from the group consisting of halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl , Substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl and the like, and R4Is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl and the like, salt.AMPK 활성화제로서 유용한 화합물을 제공한다.식: (식 중 X는 치환 혹은 비치환된 알킬, 치환 혹은 비치환된 알케닐, 치환 혹은 비치환된 알키닐, 치환 혹은 비치환된 아릴, 치환 혹은 비치환된 헤테로아릴, 치환 혹은 비치환된 시클로알킬, 치환 혹은 비치환된 시클로알케닐 또는 치환 혹은 비치환된 헤테로사이클릴이며, R1은 수소, 할로겐, 시아노, 니트로, 카르복시, 치
