LIN, KoChung,PEPINSKY, R. Blake,CHEN, Ling Ling,HESS, Donna M.,LIN, Edward Y.,PETTER, Russell C.,BAKER, Darren P.
申请号：
ES03731987
公开号：
ES2566797T3
申请日:
2003.01.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A conjugate having the structure according to Formula XXIIa: Formula XXIIa: ** Formula ** in which P is a polyalkylene glycol polymer； X is O； Z is a C1 to C20 straight or branched, saturated or unsaturated alkyl or heteroalkyl group, saturated or unsaturated C3 to C8 cyclic alkyl or cyclic heteroalkyl, a substituted or unsubstituted aryl or heteroaryl group or a substituted or unsubstituted alkaryl in the that the alkyl is a saturated or unsaturated C1 to C20 alkyl or heteroalkyl group, in which the substituents are selected from the group consisting of halogen, hydroxyl, carbonyl, carboxylate, ester, formyl, acyl, thiocarbonyl, thioester, thioacetate, thioformate, alkoxy, phosphoryl, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, sulfate, sulphonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, aromatic moiety, heteroaromatic moiety, imino, silyl, ether, and alkylthiol； R * is a binding moiety formed from the reaction of a moiety selected from the group consisting of aldehyde, aldehyde hydrate, and acetal with a biologically active compound； B is a biologically active compound, in which the biologically active compound is an interferon-beta； and n is 0 or an integer from 1 to 5.Un conjugado que tiene la estructura según la Fórmula XXIIa: Fórmula XXIIa:**Fórmula** en la que P es un polímero de polialquilen glicol； X es O； Z es un grupo alquilo o heteroalquilo C1 a C20 de cadena lineal o ramificada, saturado o insaturado, alquilo cíclico o heteroalquilo cíclico C3 a C8 saturado o insaturado, un grupo arilo o heteroarilo sustituido o no sustituido o un alcarilo sustituido o no sustituido en el que el alquilo es un grupo alquilo o heteroalcarilo C1 a C20 saturado o insaturado, en el que los sustituyentes se seleccionan del grupo que consiste en halógeno, hidroxilo, carbonilo, carboxilato, éster, formilo, acilo, tiocarbonilo, tioéster, tioacetato, tioformato, alcoxilo, fosforilo, fosfonato, fosfinato, amino, amido,
