HO, Pil Su,YOON, Dong Oh,HAN, Sun Young,LEE, Won Il,KIM, Jung Sook,PARK, Woul Seong,AHN, Sung Oh,KIM, Hye Jung
申请号：
ES12834688
公开号：
ES2687693T3
申请日:
2012.09.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A heterocyclic compound of formula 1 ** Formula ** where X1 is C, each X2, X3 and X4 is independently C or N, provided that at least one between X2, X3 and X4 is N, R1 is a mono- or poly- 3-12 membered saturated or unsaturated heterocyclyl comprising 1-3 heteroatoms (preferably heteroatoms chosen from N, O and S), in which R1 is unsubstituted or substituted with 1-3 substituents chosen from -NR6R7, -C1 alkyl -C6-NR6R7 and R8； or R1 is chosen from -NR6R7 and R8, and R2, R3, R4 and R5 can be the same or different； and each of them is independently selected from -H； -C1-C6 alkyl； C1-C6 haloalkyl； -perhaloalkyl C1-C6； -amino-C1-C6 alkyl； -C3-C8 cycloalkyl； -halogen (-F, -CI, -Br, -I)； -CN； -C1-C6 alkoxy； C1-C6 haloalkoxy； C1-C6 perhaloalkoxy； -C2-C7 alkenyl； -C2-C8 alkynyl； -Not me； -amido； -C1-C6 alkylcarboxyl； -carboxyl (-COOH)； -C1-C6 acyl； -OH； -nitro (-NO2)； -C6-C10 aryl； -heterocyclyl； and -O-C1-C6-heterocyclyl, which is a saturated or unsaturated 3-6 membered heterocyclyl bearing 1-3 heteroatoms (preferably heteroatoms chosen from N, O and S), with the proviso that if X2 is N, R3 does not exist； if X3 is N, R4 does not exist； and if X4 is N, R5 does not exist, each Y1, Y2, Y3, Y4 and Y5 is independently C or a heteroatom (preferably a heteroatom independently selected from N, O and S), provided that at least two between Y1, Y2, Y3, Y4 and Y5 are heteroatoms independently selected from N, O and S, each Y2 and Y3 can be independently substituted with R9, Y4 can be substituted with -H or -C1-C6 alkyl, each R6 and R7 is independently selected from - H； -C3-C6 alkyl； -C3-C8 cycloalkyl； -heterocyclyl； -aminomono or di-C1-C6 alkyl； -C1-C6 alkyl-amino-mono- or di-C1-C6 alkyl； -C1-C6-heterocyclyl alkyl； -C1-C6 alkylcarboxyl； and -carboxyl (-COOH)； the heterocyclyl being a saturated or unsaturated 3-6 membered heterocyclyl bearing 1-3 heteroatoms (preferably heteroatoms chosen from N, O and S), R8 is C1-C6 alkyl； -C1-C6 alkoxy； -Not me； -C1-C6-amino alkyl； -C3-C8 cycloalky
