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HETEROCYCLES DE BENZYLAMINOALKYLENE SUBSTITUES
专利权人:
NEWRON PHARMACEUTICALS S.P.A.
发明人:
SALVATI, PATRICIA,CACCIA, CARLA,MELLONI, PIERO,RESTIVO, ALESSANDRA,SABIDO DAVID, CIBELE,VALLESE, STEFANIA
申请号:
CA2542695
公开号:
CA2542695C
申请日:
2004.10.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
This invention is related to compounds of general formula (I) wherein X isoxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkylsubstituted by phenoxy or phenyl, both phenoxy or phenyl being optionallysubstituted by one or more fluoro, chloro, trifluoromethyl, C1-C6 alkyl,hydroxyl, C1-C6 alkoxy; R2, R3 are independently hydrogen, C1-C6 alkyl,halogen, trifluoromethyl, hydroxy or C1-C6 alkoxy; R4 is hydrogen, C1-C8alkyl; R5, R6 are independently hydrogen, C1-C3 alkyl, optionally substitutedby hydroxy or phenyl; R7 is hydrogen or straight or branched C1-C3 alkyl; Hetis a five to seven membered, saturated or unsaturated heteromonocyclic or aneight to ten membered, saturated or unsaturated heterobicyclic group,containing one or more heteroatoms chosen independently from nitrogen, oxygenand sulphur, said mono- or bicyclic groups being optionally substituted by C1-C6alkyl, halogen, hydroxyl or C1-C6 alkoxy; and the pharmaceuticallyacceptable salts or prodrug thereof, that are active as sodium and/or calciumchannel modulators and/or as selective MAO-B inhibitors and therefore usefulin preventing, alleviating and curing a wide range of pathologies, including,but not limited to, neurological, psychiatric, cardiovascular, inflammatory,ophthalmic, urologic, metabolic and gastrointestinal diseases, where the abovemechanisms have been described as playing a pathological role.
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