Holz, Josefin-Beate,Rossenu, Stefaan,De Bruyn, Steven,Sargentini-Maier, Maria Laura,Yalkinoglu, Ozkan
申请号：
AU2012311443
公开号：
AU2012311443B2
申请日:
2012.09.24
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Polypeptides are provided directed against IL-6R at specific dose ranges and dosing schedules that result in a prolonged effect on IL-6 mediated signaling. In particular, the invention provides pharmacologically active agents, compositions, methods and/or dosing schedules that have certain advantages compared to the agents, compositions, methods and/or dosing schedules that are currently used and/or known in the art, including the ability to dose less frequently or to administer lower doses to obtain eq uivalent effects in inhibiting IL-6 mediated signaling.
