HOLZ, JOSEFIN-BEATE,ROSSENU, STEFAAN,DE BRUYN, STEVEN,SARGENTINI-MAIER, MARIA LAURA,YALKINOGLU, OZKAN
申请号:
CA2849195
公开号:
CA2849195A1
申请日:
2012.09.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Polypeptides are provided directed against IL-6R at specific dose ranges and dosing schedules that result in a prolonged effect on IL-6 mediated signaling. In particular, the invention provides pharmacologically active agents, compositions, methods and/or dosing schedules that have certain advantages compared to the agents, compositions, methods and/or dosing schedules that are currently used and/or known in the art, including the ability to dose less frequently or to administer lower doses to obtain eq uivalent effects in inhibiting IL-6 mediated signaling.