Controlled release dosage formulations have been developed for the delivery of active agents, particularly active agents for the treatment of eye diseases or disorders, such as glaucoma. These formulations provide an effective time release of an active agent such as ECA or a derivative thereof. [Selection figure] None活性剤、特に眼の疾患又は障害、例えば緑内障の治療のための活性剤の送達のための制御放出性投与製剤が開発された。これらの製剤は、活性剤、例えばECA又はその誘導体の、効果的な時間にわたる放出を提供する。【選択図】なし