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Polymeric Hyperbranched Carrier-Linked Prodrugs
专利权人:
Ulrich Hersel
发明人:
Ulrich Hersel,Guillaume Maitro,Herald Rau,Tobias Voigt
申请号:
US14237833
公开号:
US20140243254A1
申请日:
2012.08.10
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein POL is a polymeric moiety, each Hyp is independently a hyperbranched moiety, each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs and methods of treatment.
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