POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS

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专利权人:

ASCENDIS PHARMA A/S

发明人:

HERSEL, ULRICH,MAITRO, GUILLAUME,RAU, HARALD,VOIGT, TOBIAS

申请号：

CA2843503

公开号：

CA2843503A1

申请日:

2012.08.10

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention relates to water-soluble carrier-linked prodrugs of formula (I),wherein POL is a polymeric moiety,each Hyp is independently a hyperbranched moiety,each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water- soluble carrier-linked prodrugs and methods of treatment.

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