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Polymeric hyperbranched carrier-linked prodrugs
专利权人:
Ascendis Pharma A/S
发明人:
Hersel, Ulrich,Maitro, Guillaume,Rau, Harald,Voigt, Tobias
申请号:
AU2012296950
公开号:
AU2012296950B2
申请日:
2012.08.10
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention relates to water-soluble carrier-linked prodrugs of formula (I),wherein POL is a polymeric moiety,each Hyp is independently a hyperbranched moiety,each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water- soluble carrier-linked prodrugs and methods of treatment.
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