LYERLY, HERBERT K.,OSADA, TAKUYA,HARTMAN, ZACHARY C.
申请号：
CA2954278
公开号：
CA2954278A1
申请日:
2015.07.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering a vaccine comprising a polynucleotide encoding a poiypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER2 poiypeptide or a truncation, deletion or subsiitiition mutant thereof. Methods of using the vaccine including the polynucleotide encoding the HER2 polypeptide to treat a cancer or precancer are also provided. The vaccines may be administered with a cancer therapeutic or prevention agent or a checkpoint inhibitor immunomodulatory agent.
