LYERLY, HERBERT K.,OSADA, TAKUYA,HARTMAN, ZACHARY C.
申请号：
CA2954279
公开号：
CA2954279A1
申请日:
2015.07.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding an ESR1 polypeptide or a truncation, deletion or substitution mutant thereof. Methods of using the vaccine inc luding the polynucleotide encoding the ESR1 polypeptide to treat a cancer or precancer are also provided.
