LYERLY, HERBERT K.,MORSE, MICHAEL A.,OSADA, TAKUYA,CLAY, TIMOTHY,HARTMAN, ZACHARY C.
申请号：
CA2862306
公开号：
CA2862306C
申请日:
2013.01.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HERS polyepptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided.
