Herbert K. Lyerly,Michael A. Morse,Takuya Osada,Timothy M. Clay,Zachary C. Hartman
申请号：
US15962824
公开号：
US20180311329A1
申请日:
2018.04.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER3 polyepptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided.
