PROBLEM TO BE SOLVED: To provide a production method in which adhesion to a pulverizer is reduced when a poorly water-soluble medicine is pulverized with an excipient and the pulverized material of them is obtained in a high yield, a pulverized material of them obtained by the production method, a granulated particle obtained using the pulverized material and a tablet.SOLUTION: The method for producing a pulverized material of (A) a poorly water-soluble medicine and (B) an excipient has a step for pulverizing a mixture having 4-35 mass% of the ratio of (C) water based on the total of (A) the poorly water-soluble medicine, (B) the excipient and (C) water.COPYRIGHT: (C)2013,JPO&INPIT【課題】水難溶性薬物を賦形剤とともに粉砕する際の粉砕機への付着が低減され、それらの粉砕物を高い収率で得られる製造方法、該製造方法により得られる粉砕物、該粉砕物を用いて得られる造粒粒子および錠剤を提供する。【解決手段】(A)水難溶性薬物と(B)賦形剤との粉砕物を製造する方法であって、(A)水難溶性薬物と(B)賦形剤と(C)水との合計に対する(C)水の割合が4~35質量%である混合物に粉砕処理を施す工程を有することを特徴とする、粉砕物の製造方法。【選択図】なし
