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A ENTERIC FORMULATION OF DULOXETINE AND ITS CORE AND PREPRATION METHOD
专利权人:
发明人:
申请号:
EP09834058.1
公开号:
EP2380563B1
申请日:
2009.11.04
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
An enteric formulation of duloxetine, its core and preparing method thereof are disclosed. The core comprises duloxetine or its salt and pharmaceutically acceptable excipients. The excipients include water-soluble hot melt materials selected from PEG, poloxamer, polyoxyl (40) stearate or their mixture. Based on the total weight of the core, the amount of water-soluble hot melt materials is 10%∼40% and the amount of duloxetine or its salt is 15∼60%. The core material is prepared by hot melt process. The enteric formulation comprises the core, a separating layer and an enteric layer.
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