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MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND PRECURSOR THEREOF, AND USE OF THE MOLECULAR PROBE OR THE PRECURSOR
专利权人:
KYOTO UNIVERSITY
发明人:
INAGAKI, NOBUYA,SAJI, HIDEO,TOYODA, KENTARO,KIMURA, HIROYUKI,OGAWA, YU,HIRAO, KONOMU,NAGAKAWA, KENJI,MATSUDA, HIROKAZU
申请号:
EP10808203
公开号:
EP2418216A4
申请日:
2010.08.09
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide.*-DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(1)*-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(2)*-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(3)*-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(4),in the foregoing formulae (1) to (4) *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge K* indicates that an amino group of a side chain of a lysine is protected by a protecting group and -NH2 indicates that a carboxyl group at a C-terminus is amidated.
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