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MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME
专利权人:
发明人:
Nobuya Inagaki,Hideo Saji,Kentaro Toyoda,Hiroyuki Kimura,Yu Ogawa,Konomu Hirao,Kenji Nagakawa,Hirokazu Matsuda
申请号:
US14673767
公开号:
US20150231284A1
申请日:
2015.03.30
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide.*-DESK* QMEEEAVRLFIEVVLK* NGGPSSGAPPPSK-NH2 (1) *-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (2) *-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (3) *-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2 (4), wherein *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge K* indicates that an amino group of a side chain of a lysine is protected by a protecting group and —NH2 indicates that a carboxyl group at a C-terminus is amidated.
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