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MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF
专利权人:
KYOTO UNIVERSITY
发明人:
SAJI HIDEO,INAGAKI NOBUYA,TOYODA KENTARO,KIMURA HIROYUKI,HIRAO KONOMU,NAGAKAWA KENJI,MATSUDA HIROKAZU
申请号:
EP10836003
公开号:
EP2510951A4
申请日:
2010.12.08
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide,Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) (SEQ ID NO. 1)Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (2) (SEQ ID NO. 2)B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (3) (SEQ ID NO. 3)where, in formulae (1) and (2), "X" represents a lysine residue, the amino group of the side chain of the lysine residue being labeled with a radioactive nuclide, and "Z-" indicates that the α-amino group at the N-terminus is not modified, or is modified with a modifying group having no electric charge in formula (3), "B-" indicates that the α-amino group at the N-terminus is labeled with a radioactive nuclide and in formulae (1), (2), and (3), "-NH2" indicates that the carboxyl group at the C-terminus is amidated.
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