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Molecular probe for imaging of pancreatic islets and use of the same
专利权人:
Hideo Saji
发明人:
Hideo Saji,Nobuya Inagaki,Kentaro Toyoda,Hiroyuki Kimura,Konomu Hirao,Kenji Nagakawa,Hirokazu Matsuda
申请号:
US12964486
公开号:
US08980220B2
申请日:
2010.12.09
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide,(SEQ ID NO. 1) Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) (SEQ ID NO. 2) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (2) (SEQ ID NO. 3) B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (3) where, in the formulae (1) and (2), “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a radioactive nuclide, and “Z—” indicates that an α-amino group at an N-terminus is not modified, or is modified with a modifying group having no electric charge in the formula (3), “B—” indicates that an α-amino group at an N-terminus is labeled with a radioactive nuclide and in the formulae (1), (2), and (3), “—NH2” indicates that a carboxyl group at a C-terminus is amidated.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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