The present invention relates to the crystallization of quinoline and preparation method, the pharmaceutical composition containing the crystallization and in the purposes of field of medicaments, more particularly to three kinds of crystalline solid forms of quinoline dihydrochloride, the respectively crystallization of A types, Type B crystallization and c-type crystallization, wherein A and Type B crystallization are the crystallization that the crystallization water and other solvents are free of on this, and c-type crystallization is the crystallization containing two crystallizations water.本發明涉及喹啉衍生物的結晶及製備方法、含所述結晶的藥物組合物以及在醫藥領域的用途，具體的說涉及喹啉衍生物二鹽酸鹽的三種結晶固體形式，分別爲A型結晶、B型結晶和C型結晶，其中A和B型結晶爲本上不含結晶水和其它溶劑的結晶，C型結晶爲含兩個結晶水的結晶。
