FREYNE, EDDY JEAN EDGARD,PERERA, TIMOTHY PIETRO SUREN,BUIJNSTERS, PETER JACOBUS JOHANNES ANTONIUS,WILLEMS, MARC,DIELS, GASTON STANISLAS MARCELLA,EMBRECHTS, WERNER CONSTANT JOHAN,TEN HOLTE, PETER,ROMBO
申请号：
TW101115205
公开号：
TW201245160A
申请日:
2004.05.26
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH Y represents -C3-9alkyl-, -C3-9alkenyl-, -C3-7alkyl-CO-NH- optionally substituted with amino, mono- or di(C1-4alkyl)amino or C1-4 alkyloxycarbonylamino-, -C3-7alkenyl-CO-NH- optionally substituted with amino, mono- or di(C1-4alkyl)amino- or C1-4alkyloxycarbonylamino-, C1-5alkyl NR13-C1-5alkyl-, -C1-5alkyl-NR14-CO-C1-5alkyl-, -C1-6alkyl-CO-NH-, -C1-5alkyl-CO NR15-C1-5alkyl-, -C1-3alkyl-NH-CO-Het20-, -C1-2alkyl-CO-Het21-CO-, -C1-2alkyl-NH-CO-CR16R17-NH-, -C1-2alkyl-CO-NH-CR18R19-CO-, -C1-2alkyl-CO-NR20-C1-3alkyl-CO-, or -NR22-CO-C1-3alkyl-NH- X1 represents a direct bond, O or -O-C1-2alkyl- X2 represents a direct bond, -CO-C1-2alkyl-, NR12, -NR12-C1-2alkyl-, -O-N=CH-or-C1-2alkyl- R1 and R2 each independently represent hydrogen or halo R3 represents hydrogen R4 represents hydrogen or C1-4alkyloxy R12 and R13 each independently represent hydrogen or C1-4alkyl R14 and R15 represent hydrogen R16 and R17 each independently represent hydrogen or C1-4alkyl R18 and R19 each independently represent hydrogen or C1-4alkyl optionally substituted with phenyl or hydroxy R20 and R21 each independently represent hydrogen or C1-4alkyl optionally substituted with C1-4alkyloxy Het20, Het21 and Het22 each independently represent a heterocycle selected from the group consisting pyrrolidinyl or piperidinyl optionally substituted with hydroxyl.
