Eddy Jean Edgard Freyne,Timothy Pietro Suren Perera,Peter Jacobus Johannes Antonius Buijnsters,Marc Willems,Gaston Stanislas Marcella Diels,Werner Constant Johan Embrechts,Peter ten Holte,Frederik Jan
申请号：
US12624637
公开号：
US08394786B2
申请日:
2009.11.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention concerns the compounds of formulawhereinZ represents NHY represents —C3-9alkyl-, —C2-9alkenyl-, —C3-7alkyl-CO—NH optionally substituted with amino, mono- or di(C1-4alkyl)amino or C1-4alkyloxycarbonylamino-, —C3-7alkenyl-CO—NH— optionally substituted with amino, mono- or di(C1-4alkyl)amino- or C1-4alkyloxycarbonylamino-, C1-5alkyl-NR13—C1-5alkyl-, —C1-5alkyl-NR14—CO—C1-5alkyl-, —C1-6alkyl-CO—NH—, —C1-5alkyl-CONR15—C1-5alkyl-, —C1-3alkyl-NH—CO-Het20-, —C1-2alkyl-CO-Het21-CO—, —C1-2alkyl-NH—CO—CR16R17—NH—, —C1-2alkyl-CO—NH—CR18R19—CO—, —C1-2alkyl-CO—NR20—C1-3alkyl-CO—, or —NR22—CO—C1-3alkyl-NH—X1 represents a direct bond, O or —O—C1-2alkyl- X2 represents a direct bond, —CO—C1-2alkyl-, NR12, —NR12—C1-2alkyl-, —O—N═CH— or —C1-2alkyl-R1 and R2 are hydrogen or haloR3 are hydrogen R4 represents hydrogen or C1-4alkyloxyR12 and R13 are hydrogen or C1-4alkylR14 and R15 are hydrogen R16 and R17 each independently represent hydrogen or C1-4alkylR18 and R19 are hydrogen or C1-4alkyl optionally substituted with phenyl or hydroxyR20 and R21 are hydrogen or C1-4alkyl optionally substituted with C1-4alkyloxyHet20, Het21 and Het22 are a heterocycle selected from the group consisting pyrrolidinyl, 2-pyrrolidinonyl or piperidinyl optionally substituted with hydroxy.
