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Inhibidores de cinasas de tipo piridopirimidinona
专利权人:
ABBVIE INC
发明人:
WOODS KEITH,WOODS, KEITH,MASTRACCHIO ANTHONY,MASTRACCHIO, ANTHONY,LAI CHUNQIU,LAI, CHUNQIU,GANDHI VIRAJKUMAR B,GANDHI, VIRAJKUMAR B,PENNING THOMAS,PENNING, THOMAS
申请号:
ES13707095
公开号:
ES2606640T3
申请日:
2013.02.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I): Formula ** ** where B is (a) C3-8 cycloalkyl, phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl, where the C3-8 cycloalkyl, phenyl, naphthyl, tetrahydronaphthyl, indenyl or indanyl It is substituted with one or more R5 or (b) a heterocyclyl 5-16 monocyclic, bicyclic or tricyclic members, where the heterocyclyl is optionally substituted with one or more R6 R1 is hydrogen, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, aryl, heteroaryl, aryl (C1-6alkyl) - (C3-8cycloalkyl) - (C1-6alkyl) - or heteroaryl- (C1-6 alkyl) - wherein the C1-8alkyl, C2-8alkenyl or C2-8alkynyl of R1, alone or as part of another moiety, are optionally substituted with one or more substituents independently selected from the group consisting of CN, NO2, halo, - ORa, -C (O) Ra, -C (O) ORa, -OC (O) Ra, -NRbRc, -NR b C (O) Ra, -NHC (O) NHRb, -C (O) NRbRc, -NHSO2Ra and -SO2NRbNRc and (b) C3-8 cycloalkyl, aryl or heteroaryl of R1, alone or as part of another moiety, optionally substituted with one or more substituents independently selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, heterocycloalkyl, aryl, heteroaryl, halo, oxo, CN, NO2, -ORd, -C (O) Rd, -C (O) ORd, -OC (O) Rd, -SRd, -S (O ) Rd, - SO2Rd, -NReRf -NHC (O) Re, -NHC (O) NHR e, -NHC (O) ORe, -NHSO2Rd, -C (O) NHR e and -SO2NHNRe R2 is hydrogen, halo or C1-6 alkyl R3 is hydrogen, halo, C1-6 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, C3-8, aryl, heteroaryl, heterocycloalkyl, aryl (C1-6 alkyl) -, cycloalkyl (C1-6 alkyl) -, heteroaryl- (C1-6 alkyl) -, heterocycloalkyl (C1-6 alkyl) -, C (O) R7, C (O) OR7, C (O) NR8R9 or - (C1-4 alkyl) -NR10R11, where C1 -6 or C2-6 alkenyl R3, alone or as part of another moiety, is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy and C1-6 alkoxy and where the C3-8 cycloalkyl, C3-8 cycloalkenyl, aryl, heteroaryl or heterocycloalkyl of R3, alone or as part of another moiety, is opt
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