The invention provides a substituted cyclohexyl-1,4-diamine derivativeof the formula:(see formula I)or an enantiomer thereof, a mixture of enantiomers thereof, a diastereomerthereof, amixture of diastereomers thereof, a racemate thereof or a physiologicallyacceptablesalt thereof, which may be used in preparation of a pharmaceuticalcomposition. Thepharmaceutical composition may be used for treatment of pain, anxiety, stress,asyndrome associated with stress, depression, epilepsy, Alzheimer's disease,seniledementia, catalepsy, general cognitive dysfunctions, a learning disorder, amemorydisorder as a nootropic agent, withdrawal symptoms, alcohol abuse, alcoholdependency, drug abuse, drug dependency, medicament abuse, medicamentdependency, a sexual dysfunction, a cardiovascular disease, hypotension,hypertension, tinnitus, pruritus, migraine, impaired hearing, deficientintestinalmotility, impaired food intake, anorexia, obesity, a locomotor disorder,diarrhoea,cachexia, or urinary incontinence.
