The invention provides substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-onecompounds of the general formula l(see formula I)and a method for producing the compounds. The compounds may be used to inhibitnoradrenaline or serotonin uptake in a patient and, consequently, may be usedtoprevent or treat pain, tinnitus, migraine, urinary incontinence, an anxietystate,schizophrenia, epilepsy, diarrhoea, depression, catalepsy, a food intakedisorder,alcohol abuse, alcohol dependency, drug abuse, drug dependency, aneurodegenerative disease or a cognitive dysfunction. The compounds may alsobeused for suppression of a urinary reflex, for increasing vigilance, formodulatinglocomotor activity or for regulating food intake.
