The present invention relates to a substituted cyclohexylcarboxylic acidderivative of formula I(see formula I)The derivative may be used for treatment of pain, in particular acute,visceral, neuropathic or chronic pain. The derivative may also be used fortreatmentof anxiety, stress, a stress-related syndrome, depression, catalepsy,epilepsy,Alzheimer's disease, senile dementia, general cognitive dysfunction, alearningdifficulty as a nootropic, a memory difficulty as a nootropic, withdrawalsymptoms,alcohol abuse, alcohol dependency, drug abuse, drug dependency, medicineabuse,medicine dependency, sexual dysfunction, cardiovascular disease, hypotension,hypertension, tinnitus, pruritus, migraine, a hearing difficulty, deficientintestinalmotility, impaired nutrient absorption, anorexia, obesity, a locomotivedisorder,diarrhoea, cachexia or urinary incontinence. The derivative may be used as amusclerelaxant, an anti-convulsive or an anaesthetic for co-administration intreatment withan opioid analgesic or anaesthetic； or it may be used for diuresis, anti-natriuresis,anxiolysis, modulation of motor activity, modulation of neurotransmitterrelease andtreatment of a neurodegenerative disease associated therewith or for one orboth oftreatment of withdrawal symptoms and reducing potential for addiction toopioids.
