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New 2,3-dihydro-1H-imidazo {1,2-a} pyrimidin-5-one derivatives, their preparation and pharmaceutical use
专利权人:
SANOFI
发明人:
BROLLO, Maurice,CLAUSS, Annie,EL AHMAD, Youssef,FILOCHE-ROMME, Bruno,HALLEY, Frank,KARLSSON, Karl Andreas,MARCINIAK, Gilbert,RONAN, Baptiste,SCHIO, Laurent,VIVET, Bertrand,VIVIANI, Fabrice,ZIMMERMANN,
申请号:
ES10742012
公开号:
ES2627428T3
申请日:
2010.07.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Products of formula (I): ** Formula ** in which: R1 represents a radical -L-aryl or -L-heteroaryl, such that L represents: either a linear or branched alkyl radical containing 1 to 6 atoms carbon and optionally substituted with a hydroxyl radical, either a CO group, or an L'-X group in which L 'represents a linear or branched alkyl radical containing 1 to 6 carbon atoms and X an atom of oxygen or sulfur; the aryl and heteroaryl radicals being optionally substituted with one or several identical or different radicals selected from the halogen atoms and the hydroxyl, CN, nitro, -COOH, -COOalk, -NRxRy, - CONRxRy, -NRxCORy, -NRxCO2Rz, - CORy, alkoxy, phenoxy, alkylthio, alkyl, cycloalkyl and heterocycloalkyl; the latter being alkoxy, phenoxy, alkylthio, alkyl and heterocycloalkyl radicals, themselves eventually substituted by one or more identical or different radicals selected from halogen atoms and NRvRw; the heterocycloalkyl and heteroaryl radicals may also contain an oxo radical; R2 represents a hydrogen atom or an alkyl radical; R3 represents an alkyl radical optionally substituted with one or more halogen atoms; R4 represents a hydrogen atom or a halogen atom; NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom, a cycloalkyl radical or an alkyl radical optionally substituted with one or several identical or different radicals selected from the hydroxyl, alkoxy, NRvRw and heterocycloalkyl radicals ; or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing 3 to 10 members and possibly one or several other heteroatoms selected from O, S, NH and N-alkyl, this cyclic radical being eventually replaced; NRvRw being such that Rv represents a hydrogen atom or an alkyl radical and Rw represents a hydrogen atom, a cycloalkyl radical or an alkyl radical optionally substituted with one or several identical or different radicals selected from the hydroxyl, alkoxy, heterocycloalkyl rad
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