DR. CHRISTOPH THOMAS,DR. BAHRENBERG GREGOR,DR. FRANK ROBERT,PROF. DR. LEE JEEWOO,DR. LESCH BERNHARD
申请号：
ARP120102684
公开号：
AR087301A1
申请日:
2012.07.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The present relates to pharmaceutical compositions containing these Compounds, and these compounds for use in the treatment and prophylaxis of diseases and / or Pain and / or additional disorders.Claim 1: a substituted Compound of General formula (1) wherein R0 represents an aliphatic residue of C1 - 10, not replaced or mono - or polisustituido； C3 - 10 cicloalif u00e1tico residue or residue heterocicloalif u00e1tico 3 to 10 members, in each case not replaced or Monkey In each case - or polisustituido and optionally bridged via a group of aliphatic C1 - 8Which can not be replaced or mono - or polisustituido； aryl or heteroaryl, in each case not replaced or mono - or in each case polisustituido and optionally bridged via a group of aliphatic C1 - 8Which can not be replaced or mono - or polisustituido； r1 represents h； R0, R0 (c = o) - C (= o) - O - (c = o) or0； C (= o) - nhr0； C (= o) - N (R0) 2； Oh, SH - R0, R0； S； S (= o) 2 - R0； S (= o) 2 - or0； S (= o) 2 - nhr0； S (= o) - (R0) 2 n n NH2； nhr0； 2； 2； NH (R0) s (= o) 2 - (R0, R0) (S = o) 2 - R0)； or SCL3； R2 represents h； R0； F； CL； Br； CN； NO2； Oh； SH； cf2h cfh2 cf2cl Cf3；；；； cfcl2 ch2cf3 ocf3 ocf2h；；；； ocfh2； ocf2cl； ocfcScf3 scf2h scfh2 L2；；；； scf2cl； scfcl2； S (= o) 2 - Cf3； S (= o) 2 - cf2h； S (= OR) 2 - or cfh2 Sedan； R3 represents H or an aliphatic residue of C1 - 10, not replaced or mono - or polisustituido； n represents 1 2, 3 or 4； R3A represents H or a c1-4 aliphatic residue, not replaced or mono - or polisustituido； R4A repr You have H residue or a c1-4 aliphatic, mono - or polisustituido replaced or not,A residue cicloalif u00e1tico C3 - 6, replaced or mono - or polisustituido, or an aryl, substituted or mono - or polisustituido； and represents o, s or N - CN； Z is n or C - r4b； r4b represents H or a residue of c1-4 aliphatic, mono - substituted or not or polisustituido； or R4A and Together with the u00e1tom r4b Or that connects a carbon residue forming cicloalif u00e1tico C3 - 6Not replaced or mono
