您的位置: 首页 > 农业专利 > 详情页

Aminoester Alkaloid derivatives and medicinal composition thereof
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
AMARI GABRIELE,RICCABONI MAURO
申请号:
ARP110102148
公开号:
AR081966A1
申请日:
2011.06.21
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
They act as antagonists of muscarinic receptors, processes for the preparation thereof, compositions comprising them and their therapeutic use. Claim 1: A compound characterized in that it is of general formula (1) where R1 is selected from the group consisting of C1 alkyl -6, aryl, C3-8 cycloalkyl, C1-6 arylalkyl and heteroaryl, and is optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CONHR5 , CON (R5) 2, NHCOR5, COR5, CO2R5, C 1-6 alkylsulfanyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy;R2 is H or C1-6 alkyl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON (R5) 2, NHCOR5, COR5, CO2R5, C 1-6 alkylsulfanyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy; R3 is H or is selected from the group consisting of C1-6 alkyl, aryl, C3-8 cycloalkyl and heteroaryl, and is optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON (R5) 2, CO2R5, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkyl,C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy; R6 represents a group of formulas (2) to (5) where m = 1, 2 or 3; n = 1, 2 or 3; A- is a physiologically acceptable anion; R4 is a group of the formula: --- (CH2) p --- P --- (CH2) q --- W, where p is 0 or an integer between 1 and 4; q is 0 or an integer between 1 and 4; P is a heteroaryl, and is optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NO2, CN, CON (R5) 2, NH2, NHCOR5, CO2R5, C1- alkylsulfanyl 6, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl, C 1-6 alkyl and C 1-6 alkoxy; W is selected from the group consisting of aryl, C3-8 cycloalkyl and heteroaryl,and is optionally substituted with
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充