MORIN, PAUL E.,COHEN, DANIEL,MUKHERJEE, RANJAN,REILLY, TIMOTHY P.,CHRISTIAN, ROSE C.,LIPOVSEK, DASA,CAMPHAUSEN, RAY,KRUPINSKI, JOHN
申请号:
CA2965502
公开号:
CA2965502A1
申请日:
2015.10.23
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.