Paul E. MORIN,Daniel COHEN,Ranjan MUKHERJEE,Timothy P. REILLY,Rose C. CHRISTIAN,Dasa LIPOVSEK,Ray CAMPHAUSEN,John KRUPINSKI
申请号:
US15215329
公开号:
US20170029479A1
申请日:
2016.07.20
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.