A compound of formula (1) for use in the treatment or prevention of seborrheic keratosis: ** Formula ** in which: X represents CO, CHOZ or CHNRZ； Z is selected from hydrogen； (C1-C6) straight or branched chain alkyl； straight or branched chain (C2-C6) alkenyl； straight or branched chain (C2-C6) alkynyl； (C3-C8) cycloalkyl； aryl of (C6-C24)； aralkyl of (C7-C24)； m- and p-CH2 (C6H4) COOM； COR3； CSR3； C (NR6) R3； SOR4； SO2R3R3N； SO2OM； SO2NR7R8； SO2Oartemisinyl； SO2NH-artemisinyl； POR4R5； PSR4R5； and SO2R3； R3 is selected from straight or branched chain (C1-C6) alkyl； (C1-C6) straight or branched chain alkoxy； straight or branched chain (C2-C6) alkenyl； straight or branched chain (C2-C6) alkynyl； (C3-C8) cycloalkyl； aryl of (C6-C24)； (C6-C10) aryloxy； aralkyl of (C7-C24)； - (CH2) n-COOM, in which n is an integer from 1 to 6； and 10α-di-hydroartemisinyl； R4 and R5 are independently selected from straight or branched chain (C1-C6) alkyl； straight or branched chain (C2-C6) alkenyl； straight or branched chain (C2-C6) alkynyl； (C3-C8) cycloalkyl； aryl of (C6-C24)； aralkyl of (C7-C24)； OM； (C1-C6) straight or branched chain alkoxy； (C6-C10) aryloxy； and NR7R8； R6 is selected from a straight or branched chain (C1-C6) alkyl； straight or branched chain (C2-C6) alkenyl； straight or branched chain (C2-C6) alkynyl； (C3-C8) cycloalkyl； (C6-C24) aryl and (C7-C24) aralkyl； M represents hydrogen or a pharmaceutically acceptable cation； R7 and R8 are independently selected from a straight or branched chain (C1-C6) alkyl or R7 and R8 together form an (C4-C6) alkylene bridge； and R is selected from hydrogen； (C1-C6) straight or branched chain alkyl； straight or branched chain (C2-C6) alkenyl； straight or branched chain (C2-C6) alkynyl； (C3-C8) cycloalkyl； (C6-C24) aryl, and (C7-C24) aralkyl； and where the treatment or prevention comprises the local administration of the compound to a subject in need thereof.Un compuesto de fórmula (1) para su uso en el tratamiento o prevención de la quer
