1. A method of treating or improving a disorder other than a solid tumor associated with undesired activity of CK2 protein kinase, which comprises administering to a subject in need of such treatment or improvement a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, where Z is N or CR； each R, R, R and R independently is H or optionally substituted C1-C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 heteroalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C2-C8 heteroacyl, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or C6-C12 heteroarylalkyl group, or each R, R, R and R independently represents halo, CF, CFN, OR, NR, NROR, NRNR, SR, SOR, SOR, SONR, NRSOR, NRCONR, NRCOOR, NRCOR, CN, COOR, carboxy bioisostere, CONR, OOCR, COR or NO, each R independently is optionally substituted C1-C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 heteroalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C2-C8 heteroacyl, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or C6-C12 heteroarylalkyl group, or independent Halo, OR, NR, NROR, NRNR, SR, SOR, SOR, SONR, NRSOR, NRCONR, NRCOOR, NRCOR, CN, COOR, CONR, OOCR, COR, or NO, where each R independently represents H or C1- C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 heteroalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C2-C8 heteroacyl, C6-C10 aryl, C5-C10 heteroaryl, C7- C12 arylalkyl or C6-C12 heteroarylalkyl, and where two Rs on the same atom or on adjacent atoms can be linked to form a 3-8 membered ring, optionally containing one or more N, O or S atoms； and each R group and each ring formed by linking two R groups together1. Способ лечения или улучшения расстройства, иного, чем солидная опухоль, связанного с нежелательной активностью протеинкиназы СК2, который включает введение субъекту, нуждающемуся в таком лечении или улучшении, терапевтически эффективного количества соединения формулы (I)или его фармацевтически приемлемой соли или
