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CYSTEINE PROTEASE INHIBITORS
专利权人:
Karolina Ersmark;Urszula Grabowska;Daniel Jönsson;Kevin Parkes;Ellen Hewitt;Björn Klasson;Stina Lundgren;Pia Kahnberg;Peter Lind;Lourdes Odén;Susana Ayesa;Daniel Wiktelius
发明人:
Susana Ayesa,Karolina Ersmark,Urszula Grabowska,Ellen Hewitt,Daniel Jönsson,Pia Kahnberg,Björn Klasson,Peter Lind,Stina Lundgren,Lourdes Odén,Kevin Parkes,Daniel Wiktelius
申请号:
US13514758
公开号:
US20120309673A1
申请日:
2010.12.10
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compounds of Formula IIwhereinR1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a andR2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl;R3 is a branched C5-C10 alkyl chain, C2-C4haloalkyl or —CH2C3-C7 cycloalkyl;R4′ is C1-C6alkyl, C1-C6haloalkyl or oxetany-3-yl.for use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
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