ШЭНЬ Ван (US),ЧЖАН Аймин (US),МОНГ Джэк (US),ЧЖЭН Сяолин (US)
申请号：
RU2013144571/04
公开号：
RU2013144571A
申请日:
2012.03.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound of formula (I): or a salt or solvate thereof, wherein W is N or C-CN R is a substituted aryl or substituted heteroaryl each R and R independently mean H, CC alkyl or CC cycloalkyl, wherein each CC alkyl and CC-cycloalkyl is optionally substituted with 1 to 3 groups independently selected from oxo, halogen and -OR or R and R together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclyl which is optionally substituted with 1 to 3 groups independently selected from halogen, oxo, -OR, -NRR, CC-alkyl and CC-cycloalkyl R3 is heterocyclyl containing of 1 to 3 ring heteroatoms selected from "O", "N", "S", S (O) "or" S (O) ", wherein heterocyclyl is optionally substituted with 1 to 3 groups independently selected from halogen, oxo, -OCF, -OR, -CF, -NRR, CC-alkyl and CC-cycloalkyl and each R, R and R is independently selected from H and CC alkyl. A compound according to claim 1, wherein W is N. A compound according to claim 1 or 2, wherein R 1 is substituted aryl, optionally substituted phenyl or 3-chloro-4-fluorophenyl. A compound according to claim 1, wherein R is selected from 5. A compound according to claim 1 or 2, wherein R 1 is substituted heteroaryl. A compound according to claim 1, wherein (1) each R and R independently mean H, CC-alkyl or CC-cycloalkyl, optionally methyl or (2) each R and R is optionally H or Ci-Ci-4alkyl optionally substituted with 1 to 3 groups independently selected from oxo, halogen and OR or (3) R and R taken together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclyl which is optionally substituted with up to 3 groups independently selected from halogen, oxo, -OR, -NRR, C1-C4 alkyl and C-cycloalkyl. The compound of claim 1,1. Соединение формулы (I):,или его соль, или сольват, гдеW означает N или C-CNRA означает замещенный арил или замещенный гетероарилкаждый RB и RC независимо означает H, C1-C3-алкил или C3-C6-циклоалкил, где каждый C1-C3-алкил и C3-C6-циклоалк
