KO, SOO SUNG,BATT, DOUGLAS G.,BERTRAND, MYRA BEAUDOIN,DELUCCA, GEORGE V.,LANGEVINE, CHARLES M.,LIU, QINGJIE,SRIVASTAVA, ANURAG S.,WATTERSON, SCOTT HUNTER
申请号：
CA2916504
公开号：
CA2916504A1
申请日:
2014.06.25
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed are compounds of Formula (I) and salts thereof, wherein:Formula (II) Q is: R1 is -C(CH3)2OH, -NHC(=0)C(CH3)3, -N(CH3)2, or -CH2Rd R2 is CI or -CH3 R3 is H, F, or -CH3 Ra is H or -CH3 Rb is H, F, CI, or -OCH3 Rc is H or F and Rd is -OH, -OCH3, -NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Brutons tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
