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CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
专利权人:
发明人:
申请号:
EP14740096.4
公开号:
EP3013815B1
申请日:
2014.06.25
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Disclosed are compounds of Formula (I) and salts thereof, wherein: Formula (II) Q is: R1 is &mdashC(CH3)2OH, &mdashNHC(=0)C(CH3)3, &mdashN(CH3)2, or &mdashCH2Rd R2 is CI or &mdashCH3 R3 is H, F, or &mdashCH3 Ra is H or &mdashCH3 Rb is H, F, CI, or &mdashOCH3 Rc is H or F and Rd is &mdashOH, &mdashOCH3, &mdashNHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Brutons tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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