TINO JOSEPH A,SRIVASTAVA ANURAG S,KO SOO SUNG,GALELLA MICHAEL A,LANGEVINE CHARLES M,DELUCCA GEORGE V,LIU QINGJIE,BATT DOUGLAS G,WATTERSON SCOTT HUNTER,SHI QING,BERTRAND MYRA BEAUDOIN
申请号：
IN201617002162
公开号：
IN201617002162A
申请日:
2016.01.20
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds Q is: R1 is F, Cl, CN, or CH3 R2 is Cl or CH3 R3 is C(CH3)2OH or CH2CH2OH Ra is H or CH3 each R6 is independently F, Cl, CH3, and/or OCH3 and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Brutons tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
