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SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
TINO, JOSEPH, A.,SRIVASTAVA, ANURAG, S.,KO, SOO, SUNG,GALELLA, MICHAEL, A.,LANGEVINE, CHARLES, M.,DELUCCA, GEORGE, V.,LIU, QINGJIE,BATT, DOUGLAS, G.,WATTERSON, SCOTT, HUNTER,SHI, QING,BERTRAND, MYRA,
申请号:
RSP20170904
公开号:
RS56371B1
申请日:
2014.06.25
申请国别(地区):
RS
年份:
2017
代理人:
摘要:
R1 is F, Cl, —CN, or —CH3 R2 is Cl or —CH3 R3 is —C(CH3)2OH or —CH2CH2OH Ra is H or —CH3 each Rb is independently F, Cl, —CH3, and/or —OCH3 and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Brutons tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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