Relates to compounds of formula I, where: V, W, y, and Z is CH or CR2 C1 - C6 r1 is alkyl, cycloalkyl haloalquilo C1 - C6 C3, C6, among others R2 is Halogen, alkyl of C1 - C3, C1 - C3 haloalquilo, among others R3 is hidroxialquilo C2 - or R4 C6 alkyl R4 is C2 - C6) - OC (= o) - C (H) (R5) - N (H) C (= o) - C (H) (R7) - NH2.Preferred compounds are: {2 - [4 - (3 - (4 - [(3 - cloropiridin - 4-yl) amino] - 5 - metoxipirimidin - il - 2} - 1H - indazol - 1 - yl) methyl] - 3.5 - difluorofenoxi} {ethanol, 2 - 3.5 - difluoro - 4 - [(3 - [5 - (4 - methoxy - [2 - metilpiridin IL - 4 - amino - 2 -] pyrimidin-2-yl) - 1H - indazol il} - 1} - yl) methyl] phenoxy ethanol, 2 - {3,5 - difluoro - [4 - (3 - (5 - methoxy 4 - [(3 - I Toxipiridin IL - 4 - amino - 2 -] pyrimidin-2-yl) - 1H - indazol il} - 1} - yl) methyl] phenoxy ethanol, among others.These compounds inhibit the kinase BUB1 and are useful in the treatment of proliferative DisordersSe refiere a compuestos de formula I, en donde: V, W, Y y Z son CH o CR2 R1 es alquilo C1-C6, haloalquilo C1-C6, cicloalquilo C3-C6, entre otros R2 es halogeno, alquilo C1-C3, haloalquilo C1-C3, entre otros R3 es hidroxialquilo C2-C6 o R4 R4 es (alquilo C2-C6)-OC(=O)-C(H)(R5)-N(H)C(=O)-C(H)(R7)-NH2. Son compuestos preferidos: 2-2-{4-[(3-{4-[(3-cloropiridin-4-il)amino]-5-metoxipirimidin-2-il}-1H-indazol-1-il)metil]-3,5-difluorofenoxi}etanol, 2-{3,5-difluoro-4-[(3-{5-metoxi-4-[(2-metilpiridin-4-il)amino]pirimidin-2-il}-1H-indazol-1-il)metil]fenoxi}etanol, 2-{3,5-difluoro-4-[(3-{5-metoxi-4-[(3-metoxipiridin-4-il)amino]pirimidin-2-il}-1H-indazol-1-il)metil]fenoxi}etanol, entre otros. Dichos compuestos inhiben la quinasa Bub1 y son utiles en el tratamiento de trastornos proliferativos
