PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACTION OF MORINGA OLEIFERA ROOT AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
KYONG EUK PROVINCIAL ATA;경상북도(농업기술원생물자원연구소장);안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN, HO YONG,손호용,KWON, JUNG BAE,권중배,YOO, MYUNG SUK,유명숙,LEE, JUNG HWAN,이중환,KIM, MI SUN,김미선,SOHN, HO YONGKR,KWON, JUNG BAEKR,YOO, MYUNG SUKKR,LEE, JUNG HWANKR,KIM, MI SUNKR
申请号：
KR1020160058130
公开号：
KR1020170127710A
申请日:
2016.05.12
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a functional health food product for preventing or treating thrombosis, comprising an extract of the underground part of Moringa oleifera as an effective component. Specifically, the present invention relates to a pharmaceutical composition and a functional health food product for preventing or treating/alleviating thrombosis through blood coagulation inhibition and platelet aggregation inhibition, which comprise a hexene fraction, an ethyl acetate fraction, a butanol fraction which are sequentially fractionated with an organic solvent from a hot water or ethanol extract of Moringa oleifera roots, or a mixture thereof, as an effective component. The extract of the underground part of Moringa oleifera, as an effective component of the pharmaceutical composition and the functional health food product for preventing or treating thrombosis of the present invention, shows antithrombotic activity through a potent inhibition effect on human platelet aggregation, along with an excellent inhibition effect on thrombus formation-related enzymes and blood coagulation factors. Additionally, the extract of the underground part of Moringa oleifera shows no hemolytic activity to human red blood cells, which is the problem with the extract of the overground part of Moringa oleifera； has excellent thermal stability； and does not exhibit a decrease in antithrombotic activity even in an acid environment at pH 2 and in blood plasma, and thus may be used for preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through improving blood circulation. Additionally, the effective component can be processed in various forms such as extract, powder, pills, and tablets that can be conveniently ingested at all time, and thus the present invention is extremely useful in drug and food industries.본 발명은 모링가 올레이페라(Moringa oleifera) 지하부의 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서,
