selected compound, pharmaceutical composition, method for treating a disease or disorder, use of a compound, kit for treating a pim kinase-mediated condition and invention.
ALASTAIR JAMES HODGES,ANDREW SHARPE,JASON BURCH,MINGHUA SUN,WESLEY BLACKABY,XIAOJING WANG
申请号：
BR112015006019
公开号：
BR112015006019A2
申请日:
2013.09.25
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
