ALASTAIR J. HODGES,ANDREW SHARPE,MINGHUA SUN,MIZIO MATTEUCCI,VICKIE H. TSUI,XIAOJIBNG WANG
申请号：
BR112014007203
公开号：
BR112014007203A2
申请日:
2012.09.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
