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COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE
专利权人:
发明人:
Marcia Belvin,Lori Friedman,Klaus P. Hoeflich,Jeffrey Wallin
申请号:
US14012673
公开号:
US20130345217A1
申请日:
2013.08.28
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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