Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof

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专利权人:

Eckhard Guenther

发明人:

Eckhard Guenther,Olaf Schaefer,Michael Teifel,Klaus Paulini

申请号：

US12728050

公开号：

US08470776B2

申请日:

2010.03.19

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/