Adam Golebiowski;Jack A. Hunter;Jane Far-Jine Djung;Gary P. Schrum
发明人:
Jane Far-Jine Djung,Adam Golebiowski,Jack A. Hunter,Gary P. Schrum
申请号：
US12411760
公开号：
US08158641B2
申请日:
2009.03.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors having the structure shown below:wherein R and R1 are as defined herein. The 2-arylamino-4 -(aminoalkylene)aminopyrimidines inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4 -(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.
