Christian Harcken;Brian Nicholas Cook;Wang Mao;Pingrong Liu;Jord Lord;Thomas Wei-Ho Lee;Can Mao;Hossein Razavi;Alen David Swinamer;Brian Christopher Raudenbush;Christopher Ronald Sarko
发明人:
Brian Nicholas Cook,Christian Harcken,Thomas Wei-Ho Lee,Pingrong Liu,Jord Lord,Can Mao,Wang Mao,Brian Christopher Raudenbush,Hossein Razavi,Christopher Ronald Sarko,Alen David Swinamer
申请号：
US12990248
公开号：
US08293917B2
申请日:
2009.05.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
