SPANGENBERG GERMAN,ONG ENG KOK,EMMERLING MICHAEL,LABANDERA MARCEL,PANTER STEPHEN,MENDEZ RAMIRO
申请号：
NZ60385304
公开号：
NZ603853A
申请日:
2004.04.14
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
603853 Disclosed is a substantially purified or isolated nucleic acid or nucleic acid fragment encoding citrate synthase (CS), or complementary or antisense to a sequence encoding CS, and including a nucleotide sequence selected from the group consisting of (a) sequences shown in Figures 102 and 104 hereto (SEQ ID NOS 336 and 338 to 344, respectively)； (b) complements of the sequences recited in (a)； (c) sequences antisense to the sequences recited in (a) and (b)； (d) functionally active fragments and variants having at least approximately 95% identity to the functional part of the sequences recited in (a), (b) and (c) and having a size of at least 60 nucleotides； and (e) RNA sequences corresponding to the sequences recited in (a), (b), (c) and (d). Further disclosed is a substantially purified or isolated CS polypeptide including an amino acid sequence selected from the group consisting of sequences shown in Figure 103 hereto (SEQ ID NO 337)； and functionally active variants thereof having at least approximately 90% identity to the recited sequences. SEQ ID NO: 337MSTTTTTTDESKLHDAARNRLATLSAHLLPSSTTSAALLHPIHLSSSSGISPPSNVKGTLTVVDERTGKKYTIEVSPDGTVKANDFKKISTGKNDKGLKLYDPGYLNTAPVRSTISYIDGDEGILRYRGYPIEELAEKSTFPEVAYLILYGNLPSANQLQEWEFAISQHSALPQGVLDLIQSMPQDAHPMGVLVNAISALSVFHPDANPALRGLDIYNSKQVRDKQIARIIGKITTIAAAINLRMAGRPPVLPSNKLSYTENFLYMLDSLGNRSYKPNPQLTRALDIIFILHAEHEMNCSTSAVRHLASSGVDVYTAIAGGVGALYGPLHGGANEAVLKMLSEIGSVDNIPEFIEGVX
